Sorry about that, here is a .aep with only the two frames i posted. I put A comment next to the files which one is noise reference and which is footage.
I also wouldnt reccomend using a static Image as A reference, just doesnt look natural at all. But as i said above, thats why i would record like at least 2 Sec Playback time worth of Noise Reference, and loop it if needed (would add a little fade in/ out at the point where it goes around) to make it more organic.
ALSO for sure there is some smart way to do that with some algorithm, but good luck developing that or finding someone who can do that. I certainly cant, so i would do it with the Noise Reference Footage.
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Sure there is still a bit FPN left in the Output PNG, but compare that with the unprocessed one....
I raised exposure from the DNG quite a bit btw., so good luck getting anywhere near as clean of an output Image without that Noise Reference, ill wait.
Also, as i said, you can still run that through your favorite Denoising Software and remove even more of the Leftover from that. Temporal Interpolation in AE helps a lot usually (Insanely long rendertimes sadly) for stuff like that. The .aep i posted is an fairly quick edit, so if you where to spend more time on it, and also used multiple layers, and maybe even different Noise Reference Sources from different exposure levels and a bunch of masks for different areas of the Sensor, i am fairly certain that you could still improove the output a lot, even without any actual denoising software, just with Noise Reference Footage. If you Shoot a lot on the Same Settings, one single Project file could possibly be enough to run all your footage through, with minimal fine-tuning needed i assume. Becomes a bit more work, if you use a bunch of different settings however.